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Antidepressants are medications that can help relieve symptoms of depression, social anxiety disorder, anxiety disorders, seasonal affective disorder, and dysthymia, or mild chronic depression, as well as other conditions.
They aim to correct chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior.

Antidepressants were first developed in the 1950s. Their use has become progressively more common in the last 20 years.

According to the Centers for Disease Control and Prevention (CDC), the percentage of people aged 12 years and over using antidepressant in the United States rose from 7.7 percent in 1999-2002 to 12.7 percent in 2011-2014. Around twice as many females use antidepressants as males.


Antidepressants can be divided into five main types:

List of the types of antidepressants

  1. citalopram (Celexa)
  2. escitalopram (Lexapro)
  3. fluoxetine (Prozac, Sarafem, Selfemra, Prozac Weekly)
  4. fluvoxamine (Luvox)
  5. paroxetine (Paxil, Paxil CR, Pexeva)
  6. sertraline (Zoloft)
  7. vortioxetine (Trintellix, formerly known as Brintellix)
  8. vilazodone (Viibryd)

SSRIs and SNRIs may have the following side effects:

hypoglycemia, or low blood sugar
low sodium
dry mouth
constipation or diarrhea
weight loss
sexual dysfunction
anxiety and agitation
abnormal thinking

Examples include citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil) and sertraline (Zoloft).

They are used to treat depression, fibromyalgia, some types of anxiety, and they can help control chronic pain.

Tricyclics may have the following side effects:

arrhythmia, or irregular heartbeat
nausea and vomiting
abdominal cramps
weight loss
urinary retention
increased pressure on the eye
sexual dysfunction

Examples include amitriptyline (Elavil), amoxapine- clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil) and trimipramine (Surmontil).

Monoamine oxidase inhibitors (MAOIs)
This type of antidepressant was commonly prescribed before the introduction of SSRIs and SNRIs.

It inhibits the action of monoamine oxidase, a brain enzyme. Monoamine oxidase helps break down neurotransmitters, such as serotonin.

If less serotonin is broken down, there will be more circulating serotonin. In theory, this leads to more stabilized moods and less anxiety.

Doctors now use MAOIs if SSRIs have not worked. MAOIs are generally saved for cases where other antidepressants have not worked because MAOIs interact with several other medications and some foods.

Side effects include:

blurred vision
weight loss or weight gain
insomnia and drowsiness


These medications are used not only to treat depression but for other conditions too.

The primary, or approved, uses of antidepressants are to treat:

  • agitation
  • obsessive-compulsive disorders (OCD)
  • childhood enuresis, or bedwetting
  • depression and major depressive disorder
  • generalized anxiety disorder
  • bipolar disorder
  • posttraumatic stress disorder (PTSD)
  • social anxiety disorder

Sometimes a medication is used “off-label.” This means the use is not approved by the FDA, but a doctor may decide that it should be used as it may be an effective treatment.

Off-label uses of antidepressants include:

  • insomnia
  • pain
  • migraine

Studies suggest that 29 percent of antidepressant use is for an off-label purpose.


It can take several weeks for a person to notice the effects of an antidepressant. Many people stop using them because they believe the medications are not working.

Reasons why people may not see an improvement include:

  • the drug not being suited to the individual
  • a lack of monitoring by the health provider
  • a need for additional therapies, such as cognitive behavioral therapy (CBT)
  • forgetting to take the medication at the right time

Keeping in contact with the doctor and attending follow-up appointments helps improve the chances of the drug working. It may be that the dosage needs changing or another medication would be more suitable.

It is important to take the antidepressant according to instructions, or it will not be effective.

Most people will feel no benefits during the first or second week. The full effect will not be present until after 1 or 2 months. Perseverance is vital.

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