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AICAR (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which in turn allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue.


These two functions allow for more energy conversion which helps burn fat and also sustain output in activity. This is what scientists and athletes and bodybuilders are interested in.

AICAR is fast acting, but has a short-half life and is rapidly eliminated by the body. AICAR can therefore be dosed daily. The recommended AICAR dose is 25 mg either once or twice per day. AICAR should be stored at -20°C and only reconstituted in bacteriostatic water just before use. Once dissolved, AICAR can be stored in the fridge, but it is not stable for more than 24 hours once dissolved and will lose activity after this time. This chemical is basically used for research purposes. It is used in various medicinal purposes or as rug enhancements.

AICAR has been used safely in human studies up to concentrations of 25 mg/kg with minimal side effects [8]. AICAR may provide mild side effects at the recommended dosages of 50 mg per day, however, extreme overdose of AICAR can be dangerous since it can affect blood flow to the heart.


(1) Applied in the phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis.
(2) Applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality.
(3) Applied in comestics, it is used to promote skin metabolism and make skin more tender and firm.


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